How we can react pthalamide using the Mitsunobu Reaction to get amines?

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Mohamed Ettaoussi

Can you specifiy which amine or kind of amines are you looking for!

In general after Mitsunobu reaction you make hyrazinolysis with hydrazine hydrate or N-methyl-hydrazine to generate the corresponding primary amine.

If you need some references, let me know!

good luck

Meeta Bhati

Thanks Sir

I was searching reference for the procedure to add primary amine functionality with inverted configuration.

Adel Amer

Bhati,

Try the condition reported in

---S. E. Sen, S. L. Roach, Synthesis, 1995, 756-758

Good luck