How vitamin D lowers the serum EGFR level in metastasis carcinoma breast?

11 November 2011 1 849 Report

In some literature , vitamin D supplementation is used in treatment of metastasis carcinoma breast .In functions of vitamin D, lowering of serum EGFR ( Her 2 neu ) is one of its functions .

Angel Rivera Castro

The anti-proliferative effects of 1,25-dihydroxyvitamin D3 have been linked to suppression of growth stimulatory signals and potentiation of growth inhibitory signals, which lead to changes in cell cycle regulators such as p21WAF-1/CIP1 and p27kip1, cyclins and retinoblastoma protein as well as induction of apoptosis.

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