How to treat chronic HCV infection in patient with sickle cell anemia?

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Erwa ELmakki

Our experience in treating chronic active HCV infection in patients with sickle cell anemia is limited.We are giving either peg-interferon monotherapy or combination therapy (peg-interferon+low dose Ribavirin ),also the role of protease inhibitors eg: Telaprivir and Boceprivir in treating such group of patients is not well understood.

Arvind Singh

Please have a look at these useful links.

https://academic.oup.com/cid/article/65/5/864/3824877

https://www.karger.com/Article/FullText/493421

Gamal Abdul Hamid

Clinical trial results show that Zepatier (elbasvir/grazoprevir) is highly effective against hepatitis C virus (HCV) infection in sickle cell disease patients and others with inherited blood disorders.

The study with these findings, “Elbasvir/Grazoprevir for Patients With Hepatitis C Virus Infection and Inherited Blood Disorders: A Phase III Study,” was published in the journal Hepatology.

https://sicklecellanemianews.com/2017/03/09/zepatier-effective-against-hcv-infection-in-sickle-cell-blood-disorders-in-clinical-trial/

Treatment of chronic hepatitis C in sickle cell disease and thalassaemic patients with interferon and ribavirin

Article Treatment outcome of chronic hepatitis C in sickle cell dise...