Hi,
I have a problem when use the CDOCKER protocols of Discovery studio .
I tried to dock the ligand to my protein which arelady have a small molecules at the active site.After preparing protein and ligand, defining binding sites from receptor cavities ,i use the CDOCKER protocols.Except for Top hits=100,Pose Cluster Radius=0.5 ,other parameter is default.
But i got failed results,it says "failed ligands" "No refined poses found for ligand ".
And i adjust the diameter of Binding site,Pose Cluster Radius to 1,and Ligand Partial Charge
Method,but failed.
Can anyone tell me how to solve this problem