How to show increased glycolysis by metformin in vivo?

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Emin Grbic

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Rafi al-razzuqi

Dear Ms Jolien

Good morning

I am Pro Dr. Rafi AM Al-Razzuqi ... a researcher in the complications of diabetes mellitus ...

Please read for metformin mechanism of action at cellular level.. It will answer your question.

Best wishes

Jolien Vandewalle

Dear Rafi, Figure 1 in following paper: Madiraju et al. Nature 2014, 510 (542-546) coud show increased lactate levels and decreased glucoselevels after administration of metformin, however I'm not able to reproduce this. Do you have any recommendations on this?

Many thanks in advance,

Jolien