One of the deprotection reaction was done using Zinc Chloride using THF:Water as a solvent. After the deprotection, our compound and zinc chloride was soluble in water, so it can't able to extract with ethyl acetate or DCM solvents.
So, How can able to separate Zinc chloride from the reaction mixture...???
Dear friend Nagarajan Nagasundaram
One possible method to separate Zinc Chloride from the reaction mixture is by precipitation. Addition of a salt that forms an insoluble compound with Zinc Chloride, such as Sodium Carbonate or Sodium Phosphate, can lead to the formation of a precipitate that can be filtered and separated from the solution. Another method is by using a cation exchange resin, such as Amberlite IRC-718, which can selectively bind and remove Zinc ions from the solution.
References:
1. Pavia, D. L., Lampman, G. M., Kriz, G. S., & Vyvyan, J. A. (2014). Introduction to organic laboratory techniques: A small scale approach (4th ed.). Cengage Learning.
2. Kaneda, T., & Nozaki, K. (1987). Cation-exchange chromatography of transition metal ions with Amberlite IRC-718 resin in hydrochloric acid media. Analytical chemistry, 59(19), 2349-2352.
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