What is the role of ether solvent (such as THF) in Sonogashira coupling?

Can Amine (such as Et3N) be used as solvent as well as base for the Sonogashira Coupling? How to decide the amount of solvent to be used in any reaction? Does the amount of solvent affect the...

14 February 2021 4,018 3 View

IC50 value from this graph?

01 January 2021 6,848 4 View

How Architecture is related with Culture?

How architectural form, shape, style and technique are influenced by Cultural Values and Norms?

05 October 2020 6,651 17 View

Do we really pay serious attention to balance such factors for good design affecting in Human comfort?

It has been recognized that Architecture is influenced by many factors like, Social, Physical, Cultural, Environmental, Economic and Political etc.

04 October 2020 5,867 10 View

What is the best Free/Open Source software for doing Taguchi and other design of experiments and associated meaningful analysis like ANOVA?

Also what are the different efficient DOE and Analysis methods w.r.to machining operation with a specially sintered tool?

03 August 2020 4,553 3 View

What is the current research scenario related to solid lubrication & solid lubricant based cutting tools?

What according to you should be researched/accessed with respect to WC based solid lubricant tools? What is your view with respect to future research in this area? (For e.g. Tribological study...

19 July 2020 3,232 6 View

Can I freely use figures from open access journals/articles by citing the article?

I am writing a review paper. In my paper, can I use figures from "open access" journals/articles etc provided I cite them properly? (i.e. without have to go for requesting permission for using)....

02 July 2020 9,363 15 View

Which circuit design should I use to generate emf oscillating at frequency of 2.5Ghz ?

I am looking for a circuit which can generate an emf oscillating at frequency of 2.5Ghz. My setup is in such a way that, I am passing particles (negligible mass) from a tunnel and want an emf...

21 December 2019 9,800 6 View

Why Biosurfactant production varies with the carbon sources?

Some Pseudomonas sp. are reported for biosurfactant production with glucose as a carbon source, where as other Pseudomonas sp. reports the significant BS production with hydrocarbon. Why?

12 November 2019 282 3 View

Under what circumstances can we consider mass equivalent to weight and vice versa ?

Can mass be always considered equivalent to weight ?

17 September 2019 7,790 3 View

Could you recommend any books about Number Theory?

Beginner level books. High level books. Analytical Number Theory. Algebraic Number Theory. Combinatorical Number Theory. Books about partitions. Books about primes.

03 March 2021 7,174 5 View

Can linear DNA be used as template for site-directed mutagenesis?

Is it possible to induce site-directed substitution mutation by quick-change method on linear dsDNA? or it has to be cloned in some vector? If yes, should it be treated with the Dpn1 enzyme...

03 March 2021 401 4 View

What is the best way to keep an anaerobic chamber anoxic in the absence of hydrogen?

I'm a graduate student who works with an anaerobe, so I often work in an anaerobic chamber. I've been working on an assay that involves the steady-state of the quinone/ quinol pool. Anoxic...

03 March 2021 2,971 1 View

How to increase a model accuracy ?

dear community, my model is based feature extraction from non stationary signals using discrete Wavelet Transform and then using statistical features then machine learning classifiers in order to...

03 March 2021 6,994 5 View

How do I increase the yield of my PCR product?

Hello, We would like to increase the yield of our PCR product. We are running a series of PCR reactions that is targeting ~1.1kb sequence. We begin each reaction with ~400pg of template DNA...

02 March 2021 4,029 3 View

Arena simulation - how do i model the following model in ARENA (see description) (new to ARENA)?

Hello, I'm fairly new to ARENA and I have the following problem: I have two queues in which, in each queue, a different order type arrives (both having an arrival rate of exponential 10). Order...

02 March 2021 2,431 3 View

PACYC PCR not working after several attempts. Would anyone have any suggestions?

So, I have been trying to run a pACYC PCR which will be used later on for a Gibson Assembly. However the PCR is not working. I have already tried gradient PCR and changing extension time; however...

02 March 2021 1,146 2 View

How to address this issue in the analysis of Real-Time PCR results?

To dear Researchers, I was analyzing a series of concentration for estimation of Real-Time PCR efficiency. The concentration was 1:10. I used MS-excel to evaluate Slope. The result of slope was -8...

01 March 2021 8,683 4 View

What is the indication of the absence of peaks in Methanol electrooxidation CV curves ?

I have several question regarding the MOR; hope anyone help me better understand. 1- in CV using (KOH+MEOH) what is the indication of absence of the redox peaks? shouldn't they exist as a sign...

28 February 2021 4,851 8 View

Is there a deep reason for using the squared modulus of the wave function as the probability density of the existence of the particle?

I think we were all surprised at the first time we got to know quantum mechanics that the squared modulus of the wave function is the probability density of the existence of the particle? The role...

28 February 2021 6,282 9 View