I've been doing a bit of reading and found that insoluble nanoparticles like TiO2 are insoluble in water, so when they enter the body they are extremely slow to be removed. Exposure is common because they're used in everything from paint, toothpaste, sunscreen, foods, etc. So repeated exposure will cause and increase in TiO2 level overtime. What theoretically could be done to remove this TiO2 build up? I was thinking that a blood transfusion (or some particle filtering system similar to dialysis) could be done, find some sort of binder that binds to TiO2 specifically to aid in removal, or removal by sweat or ultrasonic vibrations? Any other thoughts?
Dear Scott Daniska, hope the following attached docs will bring some addition and help. My Regards
Thanks for the interesting question. To my best knowledge the problems of nanoparticles toxicity and pharmacokinetics are not yet resolved. Tons of paper are published in this area, just google "nanomedicine."
Scott Daniska what is the limit concentration of TiO2 that could affected body
Karim Tanji I don't know much about concentration, but there is a lot of evidence that shows that TiO2 is considered "safe" because it doesn't pass through the GI tract well. Well think about it the other way. Once these NPs get into your body, they're not going to leave well either. There's very little research on this topic and I think we need way more. I suspect that the implications of this problem prevent grants from funding this research (for example look at the resistance of lead research back in the 70s)
This is a good starting point to look at research on nanoparticles funded by EPA
https://www.epa.gov/chemical-research/research-nanomaterials
Yurii V Geletii I would like to see some studies looking for various environmental nanoparticles in various disease states... wouldnt that be interesting
The toxicity studies of various Nps is in the early stage and long term effect of these particles in the living system is yet to be found out.
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