During cancer treatment, mostly drugs target proliferating cells and hence normal cells also dye along with cancer cells and so result in side effects. So is there any trial going on to use MSCs in those patients to reduce the side effects after chemotherapy?
Does MSCs mean Multidisciplinary Supportive Care or Multipotent Stem Cells?
Hi Dr Ahmad,
Generally speaking, one efficient way to reduce the side effects of chemotherapy is drug targeting using nanotechnology.
Targeted drug delivery for cancer / tumor have shown a sharp rise recently. While compared to the successful pre-clinical studies, only 15 passively targeted nanocarier systems have been approved for clinical use and none of the actively targeted nanocariers have previously gone through advanced clinical trials.
Development of more efficient and more predictive preclinical animal models and adoption of GLP and standardization guidelines in academia are necessary to bridge the bench-bed gap. Such standardizations (that should include better size, surface and toxicity characterization) coupled with better understanding of tumor biology and identification of real biomarkers that can predict responders and non-responder in advance will most likely increase the success rate of translation of novel nanocariers into clinical practice. The Nanotechnology Regulatory Science Research Plan and similar programs established by the health authorities should be employed to evaluate the efficacy and safety of nanocariers, hence unleashing their real potential.
Source: Progress and challenges towards targeted delivery of cancer therapeutics. NATURE COMMUNICATIONS | (2018) 9:1410.
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