We have been lyophilizing several nanoparticles like iron oxide, cerium oxide to get powder sample. However, for gold nanoparticles and any other NPs with gold, they turn sticky after lyophilizing instead of forming powder. Literatures mention they took XRD but I didn't find much on how they prepared the powder sample. One of the literatures suggested using filter paper but nothing really collected in the filter paper when filtered. Any suggestion on how I could get powder GNP for XRD?
Thank you!
Nasser Mostafa
, I did think of it, however I was worried if wetting the already dried sample in the process would be a problem. Regardless, I’ll try it. Thank you.
Hi Trishna Timalsena, I think that the capping ligand on gold nanoparticles might be responsible for the sticky texture, because I have lyophilized gold nanoparticles capped with DNA and it was a powder. I would suggest to prepare more concentrated nanoparticles by repeated centrifugation while simultaneously removing the excess capping ligand. You also need to make sure that the nanoparticles are dried prior to lyophilization (I'm sure that you are aware of this, but just a note). Wish you good luck!
Shaila Thakur I'll try centrifuging the GNP. I've performed XRD with the sticky material and I can see a bulk gold phase but there are many additional peaks that I cannot account for. Thanks for the suggestion.
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