I'm using isoflurane as the anaesthetic agent for my lab rats. The isoflurane provided by sigma is in mg form and I'm planning to dissolve it in ethanol (for drop jar method). But I'm not sure how many milligrams of isoflurane powder need to be dissolved in 100mL ethanol to give good anaesthetic effect. If anyone have prior experience with isoflurane powder, please advise me about the preparation. Thanks in advance
Isoflurane is a volatile liquid general anaesthetic agent supplied in pure form.
It's boiling point is 48.5c at STP.
It is NOT a solid in powder form,and you will therefore not need to solubilise it.
There are also a large number of articles regarding the use of isoflurane in veterinary medicine and with respect to rats ,which may be useful.
https://en.wikipedia.org/wiki/Isoflurane
https://scholar.google.co.uk/scholar?hl=en&as_sdt=0%2C5&as_vis=1&q=isoflurane+anaesthesia+rats&btnG=
This might be useful
https://www.mcgill.ca/research/files/research/110-mouse_anesthesia_0.pdf
Never heard if this - but good to know - why not use inhalational drug?
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