I am trying to do in vivo study using Bindarit, a CCL2 inhibitor. I'm facing trouble to make solution /suspension of bindarit in methyl cellulose...when compound is added to 0.5% methy cellulose, a white suspension is produced but even after sonication the compound does not disperse well to be drawn by syringe to perform i.p. injection to mice. Does anybody face similar problem using the compound. Any advice/suggestion is highly appreciated. Would you please suggest which route is better administer the compound-oral gavage or i.p.?

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