Dear colleagues,
I currently work on bulk polycondensation for biodegradable polyesters (glycerol + polyols) synthesis. When the Mw is increased, the PDI became broad. How can the PDI be kept as low as possible, like 2 to 3, while the Mw of the prepolymer keep increasing? Thank you for your precious suggestions.
Dear Jacky Tsai, please check the following papers. Many documents are free downlable on google. My Regards
https://doi.org/10.1016/0032-3861(92)90340-3
https://www.nature.com/articles/pj200239
Dear Jacky, linear polyesters have a theoretical PDI limit of 2. That is, their polydispersity is naturally controlled. However, when you add multifunctional monomers (e.g. glycerol), this is no longer the case. Maybe you can control your PDI by adjusting (reducing) the amount of glycerol in the compositions, or by adding glycerol at the end of the process, not from the beginning. On the other hand, pay attention to the mixing process. If mixing is inadequate, your PDI can also increase.
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