How to inhibit PI(4,5)P2 synthesis?

Snezhanna Medvedeva @Snezhanna-Medvedeva

08 July 2022 0 1K Report

Hi, I'm working with inflammatory bowel disease model in mice and I'm interested in investigating interactions between tight junctions, actin cytoskeleton and lipids. I'm looking for inhibitors of PI(4,5)P2 synthesis to treat gut organoids or explants with it. It can be inhibitors of PI4K (which creates PI4P - substrate for PI(4,5)P2), but the efficient decrease in PI(4,5)P2 level is necessary. Does anybody faced something suitable?

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