Imagine having access to the complete three-dimensional structures of all proteins in a bacterial species. What computational and analytical approaches would you use to identify:

1️⃣ Key proteins essential for bacterial survival or pathogenesis?

2️⃣ Immunogenic domains that could serve as potential vaccine targets?

3️⃣ Effective B-cell and T-cell epitopes for immune response stimulation?

I would love to hear about the methodologies, bioinformatics tools, and experimental validation strategies that could be employed in this context. Any insights or references to relevant studies would be greatly appreciated!