Dear Dr Ibrahim Rashid

Hi

I find this model in rats ,you can see this paper entitled" Establishment of Rat Model of Hyperuricemia and Efficacy Evaluation of Positive-Control Drugs" in below link:

https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.lb323

Dear colleages,

Potassium oxonate (and its combinations with adenine) can also be used in mice (and a very informative article concerning rats has been cited by Ali Sepehrinezhad ) as well as purine sourses such as yeast extract . The problems in both rodents species may arise due to reversability of metabolic changes. The absence of knockout animals is very close problem for us, still there are other ways of modelling with final choice depending on the aim of your experiments.

Regards,

Olga Tovchiga