How to find maximum tolerated dose for novel drugs?

11 June 2015 1 4K Report

We have developed new anticancer molecules and I want to study the Maximum tolerated dose of These chemicals in healthy individuals. Can anyone tell me what tests are used for that or can provide me literature to read about the same.

Thank you.

Supriya Mallick

You may please follow this link http://www.fda.gov/downloads/Drugs/Guidances/UCM078932.pdf.

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