Hi all:
To my knowledge, juglone （5-hydroxy-1,4-naphthoquinone） is a natural product with confirmed anticancer and antibacterial activity. My study is to reveal the antibacterial mechanism of action of juglone using a proteomic method. But, some papers have reported its mutagenic and tumorigenic effects so it seems contradictory. My question is how to argue the antibiotic potential outweighs the carcinogenic risks. If anybody know it please tell me. Thanks in advanced!
Jiayi
14 August, 2016
Dear Jiayi! Please, read carefully the paper in the Attachment. You will find all answers.
Vladimir
Dear Jiayi,
Many pure natural products have side effects, and chemical synthesis may decrease some of these effects.
In medicinal chemistry, the most important is to have an effect (ex: antibacterial) if there are others effects (ex: mutagenic and tumorigenic) of the lead molecule (ex: juglone), chemists add or remove some atoms to decrease these effects.
Respected Prof. Vladimir, Thanks for your reply and help. I firmly believe this attachment was very useful for me. After reading the PDF, I want to argue this problem at the dose point that juglone's MIC was lower than its mutagenic and tumorigenic dose. Whould you please give some advices?
Dear Naïrouz, thanks for your reply. Does your suggestion belong to the QSAR subject?
Dear Jiayi,
Your arguments are logical. All substances have side effects. For all pharmaceutical substances it is also possible to speak in the affirmative. Specific and side effects depend on the dose of substances and sensitivity to substances of the object, which is exposed to the substance. Please, remember about it.
Vladimir
Dear Jiayi,
QSAR is one part of studies in Medicinal Chemistry.
Very interesting book on Medicinal Chemistry like : Graham L. Patrick Introduction to Medicinal Chemistry, but you can find many important books.
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