02 February 2017 3 2K Report

This may be general knowledge to genetics experts out there, but I have a question regarding how to estimate carrier probabilities.

Let's say the MAF at a given allele is 0.12 in a population in HWE. What is then the probability for an individual in that population of carrying that allele (on 1 or both chromosomes)?

I am curious to find out whether there are different ways to calculate this.

Thanks in advance,

Tina

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