I am running experiment where I am trying to crystallize the complex of one protein and potential inhibitor, but I am having problem dissolving inhibitor in different organic solvents, therefore I cannot concentrate it with the protein and set up the crystal drops.

I have tried dissolving it solely in DMSO, methanol, ethanol, acetic acid, acetate nitrate and buffer (HEPES+NaCl+glycerol+DTT) but I cant fully dissolve it.

DMSO works the best but under the microscope at even very low concentrations I can see the precipitation.

Also tried to mix up the DMSO+PBS; DMSO+corn oil but still doesn't help.

Does anybody has any suggestions? I have posted up inhibitor image in case it can help.