I am working on the effect of topical curcumin on ligature induced periodontitis in wistar albino rats. We have used a gel base which delivers curcumin for 24-48 hours. We confirmed the duration of activity using paw edema method, but the drug release rate is only 60% when the gel is applied and inflammation is induced using 0.1% carrageenan. We have treated 1 group with the same gel.