I have developed a nanocomposite of two different systems. Individually, one of the systems is a good T1 contrast agent and the other is a good T2 contrast agent. Interestingly, both of them share a common magnetic metal element Mn. The T2 system also contain an additional magnetic metal element Fe.
Now, if I have to calculate the r1, r2 values from metal concentration (mM) variant relaxation rate, concentration of what I should consider in each case? Don't forget the fact that they share a common element Mn
.
If my question is not clear enough, I am ready to illustrate more.
Do you have an estimation on r1 and r2? Based on your estimation, you can prepare a series of samples at different concentrations, such as 0, 0.2, 0.4, 0.6, 0.8 and 1 mM, and measure the T1 and T2 values, respectively. Then, plot of [C] vs 1/T1 which slop will be r1, plot of [C] vs 1/T2 which will be r2. If you did not obtain linear plots, your concentrations might be too high. Good luck!
You need to figure it out by yourself. If you had a fixed ratio of Mn_m / Fe_n, you could try to plot [Mn_mFe_n] versus 1/T1 or 1/T2. You need to report r1 or r2 in unit of s^-1mM^-1[Mn_x Fe_y] so that the readers would know what are the dominant species.
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