Although the malignant tumors at the initial stage from the stemness starts as a Monoclonal origin, upon the further proliferation, a secondary clonal population of cancer cells are generated. This further continues to go and change the clonality.
Hence, do the malignant tumors need to be addressed as a monoclonal or polyclonal?
http://onlinelibrary.wiley.com/doi/10.1002/path.2793/pdf