I want to insert EGFP gene into MTb genome using CRISPR system. Is it right to  design gRNA targeting an essential gene and HDR template (1.5kb)? I design is just the last 400 bp of one gene1 with no stop codon immediately followed by EGFP and the 400 bp of gene 2. I mean the gene 1 and EGFP will be expressed as a single ORF. I need suggestions.