How to decide a dose of novel drug if there is no reference for it in rodents?

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What arte different staining technique used for neurodegeneration?

Staining techniques for 4% paraformaldehyde and PBS fixed brain tissue

02 March 2019 4,749 5 View

Best and simple silver staining technique with procedure??

silver staining for paraformaldehyde fixed brain sections

02 March 2019 6,491 3 View

What should we do unilateral or bilateral cannulation for behaviour study in rodent brain?

reason to do that?

01 February 2019 1,165 2 View

What is the most Operating System (OS) which can be INSTALL on Tiny hard devices like Raspberry Pi (RPi) hardware ?

I'm targeting to deploy a mesh network and manually configure MANET routing protocols. I'm preparing scenarios, architectures, and hard devices needed to do that. Are there some step-by-step...

03 March 2021 1,931 5 View

Can we classify HV and LV lines based on line length?

I have dataset which shows the length of power lines. I need to classify the lines based on the line length. Is there a rule to classify the High voltage (HV) and low voltage (LV) lines based on...

03 March 2021 4,116 4 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

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Is there a classification scheme for rock cavities or caverns with respect to their size and shape?

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Is there a powerful system for the security of the systems distributed on IoT systems?

02 March 2021 3,858 10 View

How can we calculate the sample size for rodents for a particular period of time?

How can we calculate the sample size for rodents for a study for one year? Are there any specific protocols to be followed for designing rodent sampling? How long should be the sampling interval...

01 March 2021 1,056 3 View

Would fecal samples stored at -20C for over a year impact metagenomic analysis?

Dear All, I have access to some rodent fecal samples that have been stored at -20C instead of -80C. Anyone have experience with the impact of stowage condition on comparative metagenomic analysis...

01 March 2021 2,512 1 View

Which is suitable for use with Python? MySQL or SQL Server?

Which is suitable for use with Python? MySQL or SQL Server? What is your suggestion?

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What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

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How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

Paul S Garcia

If the drug has ever been used in another in vivo model, we translate doses by body surface area (BSA). If it has never been tried, test several concentrations on a logarithmic scale (e.g., 0.3 1 3 10 30 100 uM). These might have to be class E tests through your institutional ethics committee.

s. Béatrice Marianne Ewalds-Kvist

Mice or rats? A mouse is 30 g, a rat about 300 g. There are web calculators for BSA:

https://www.calculator.net/body-surface-area-calculator.html