How to decide a dose of novel drug if there is no reference for it in rodents?

More Paras Patni's questions See All

For modelling epoxy-based matrices (in composites), which model in ABAQUS is the most suitable, Concrete damaged plasticity or Drucker-Prager model?

I am working on developing a micromechanical FE model for predicting kink-band formation in UD composites. To model matrix plasticity, which model, out of Concrete Damaged Plasticity and...

28 February 2021 5,415 1 View

How to derive the expression for the View Factor of a configuration of two bodies, starting from the general case ?

Hi all : Please, I need some help on Heat Radiation Transfer: How I can derive the formula of the View Factor for a particular configuration, in a way of ending with an expression for the VF as...

15 May 2020 4,929 6 View

Radiation Heat Transfer between a Hot body and a real Surface ?

Hi all , How can I consider the Optical properties of a surface into the Stefan-Boltzmann law for a problem of Radiation Heat Transfer between a hot Body and a real Surface (namely, a surface...

15 May 2020 9,449 8 View

Is this a well defined Integral ? If so, does anyone can help me to solve it ?

Dear all : I need to solve the following integral (attached as an image file) The context is on the calculation of View Factors in Radiation Heat Transfer I worked out the this expression from...

15 May 2020 7,500 16 View

How to calculate the Solar Radiative Flux arriving to a Solar Plate Collector placed on the surface of Earth ?

Hi all, I'm trying to perform a calculation on the Flux due only to radiation, received at the surface of a Flat Plate Solar Collector placed on the surface of the Earth. The collector is tilted...

14 May 2020 604 24 View

Air Velocities and Temperature Distributions inside an enclosed air cavity, modeled in COMSOL Multiphysics ?

Dear all : I'm trying to solve the following problem using COMSOL Multyphysics. I have an enclosed geometry (please see the attached images) with a top flat surface (the celing) and an undulated...

19 March 2020 7,455 5 View

Simulation of an Air Solar Plate Collector in COMSOL Multiphysics. Problems with defining the Boundary Conditions ?

Dear all: I need help, I hope there is someone out there who can help me. I finish drawing the 2D geometry of an Air Solar Collector with an undulated absorber plate (in contrast with a flat...

19 March 2020 5,935 9 View

Does the value for the Seebeck Coefficient (S) measured with a Voltmeter can really be taken as the S of the test material ?

Hello to all : This question is originated from the idea that every material (except for Superconductors) has a Seebeck Coefficient (S) different than zero, and from the idea that in every case...

19 March 2020 4,192 5 View

Geophysical response of Water uptake by trree?

When plant takes water from.the soil and the water is transpired by the stomata, is it possible to measure the SP potential...if it is attempted by any one, can you share what kind of electrode...

08 March 2020 6,726 3 View

Diffusion of Carbon atoms in Bismuth Telluride ?

Dear Colleagues : Does anyone have literature referencing the diffusion process of Carbon (I mean Carbon atoms) into Bismuth Telluride (Bi2Te3) or into some other compound alike ? E.g. PbTe,...

05 March 2020 2,976 2 View

What is the most Operating System (OS) which can be INSTALL on Tiny hard devices like Raspberry Pi (RPi) hardware ?

I'm targeting to deploy a mesh network and manually configure MANET routing protocols. I'm preparing scenarios, architectures, and hard devices needed to do that. Are there some step-by-step...

03 March 2021 1,931 5 View

Can we classify HV and LV lines based on line length?

I have dataset which shows the length of power lines. I need to classify the lines based on the line length. Is there a rule to classify the High voltage (HV) and low voltage (LV) lines based on...

03 March 2021 4,116 4 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

03 March 2021 1,401 3 View

Is there a classification scheme for rock cavities or caverns with respect to their size and shape?

The range of forms and sizes of cavities in rock is very big. Is there a classification scheme for rock cavities regarding their size and shape?

02 March 2021 4,511 3 View

Is there a powerful system for the security of the systems distributed on IoT systems?

02 March 2021 3,858 10 View

How can we calculate the sample size for rodents for a particular period of time?

How can we calculate the sample size for rodents for a study for one year? Are there any specific protocols to be followed for designing rodent sampling? How long should be the sampling interval...

01 March 2021 1,056 3 View

Would fecal samples stored at -20C for over a year impact metagenomic analysis?

Dear All, I have access to some rodent fecal samples that have been stored at -20C instead of -80C. Anyone have experience with the impact of stowage condition on comparative metagenomic analysis...

01 March 2021 2,512 1 View

Which is suitable for use with Python? MySQL or SQL Server?

Which is suitable for use with Python? MySQL or SQL Server? What is your suggestion?

01 March 2021 3,422 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

Paul S Garcia

If the drug has ever been used in another in vivo model, we translate doses by body surface area (BSA). If it has never been tried, test several concentrations on a logarithmic scale (e.g., 0.3 1 3 10 30 100 uM). These might have to be class E tests through your institutional ethics committee.

Béatrice Marianne Ewalds-Kvist

Mice or rats? A mouse is 30 g, a rat about 300 g. There are web calculators for BSA:

https://www.calculator.net/body-surface-area-calculator.html