Dear all,
I need some guidance or clarifications on how to calculate the effects of the combinations of insecticides when you have the adult mortality rate of individual products and of their mixture.Example: Product A: 78%; B: 50% C: 65% and their mixture 89%.
When I looked in Insecticide Resistance Monitoring, Mechanisms and Management Manual I was confused with their calculations. Best regards
Thanks in advance
Insecticide Mixtures Could Enhance the Toxicity of insecticides i.e., synergism effect and this is an important resistance management tool in pest insects such as Bimisia tabaci, Musca domestica and mosquitoes etc. You can see the attached files further to know the combination effects and for getting help in calculation of mixture effects. thanks
best regards
Insecticides can sometimes act as a synergist when they are added with another insecticide. Simply taking an example, WHO clearly classifies the percentages attributing to the susceptibility status of different vectors of malaria as susceptible including synergist (mortality- >/=98%), possible resistance (mortality- 90-97%)and confirmed resistance(mortality=
I will suggest using joint toxicity equations. The joint application of insecticide A and B in different proportions led to synergistic or antagonistic interaction
Joint Toxicity equations are as follows
Joint Toxicity = Actual toxicity index (T.I) of a mixture (M)/Theoretical toxicity index (T.I) of a mixture × 100
Actual T.I of a mixture = LC50 of standard agent/LC50 of mixture (M)
Theoretical T.I of a mixture = (T.I of agent a × % of agent a in M) + (T.I of agent b ×
% of agent b in M)
T.I = LC50 of standard agent/LC50 test sample
I will recommend the following article for a better understanding
Article Toxin-Pathogen Synergy Reshaping Detoxification and Antioxid...
I think, to understand these interactions (insecticides A,B,C) we should test all combinations - a+b, b+c, a+c, a, b, c and control. Only this way allow to calculate synergistic or antogonistic effects. Methods of calculation may be different
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