I am taking equal amount of octanol and water and adding sufficient quantity of drug in the mixture. But log p is coming 3.66 whereas reported value is 1.52
Dear Rubiya Khursheed,
Please check your buffer (should have pH 7.4) next check your quercetin purity. Aglycons are usually more lipophilic than conjugates. It was reported that quercetin and other flavonoids can give very variable results of LogP. Please check values of LogKw (by RP-HPLC) presented in poster below. I think its close to your observation.
Article Experimental Determination of Octanol−Water Partition Coeffi...
Article The lipophilicity indices of flavonoids estimated by reverse...
https://chem.pg.edu.pl/documents/30625396/30654294/poster%20ExTech2018_TC.pdf
Best regards
Tomasz
It may be due to several reasons:
1) If the drug shows polymorphism - The reported value may of a different polymorphic form of the same drug, but in case if
you are using the another polymorph the results can be different based on solubility criteria of the polymorphs.
2) The grade/quality/purity of octanol used.
3) Accuracy and precision of the analytical method employed for the estimation of drug present in both the solvents (layers).
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