Dear all,
We are working with mouse liver microsomes to evaluate the metabolic stability of some compounds.
We calculated the t1/2 of some of these compounds and now we would like to understand how to calculate the intrinsic clearance with these parameters. Then we would like to transform these results to in vivo predictive values.
Thank you very much for your help.
Zaim Gashi
One possibility:
Hepatic Clearance: Cl(h) = Q [(f x Clint)/(Q+ f x Clint)]
Q = hepatic blood flow
f = fraction of free drug (not bound)
Clint = intrinsic capacity of the hepatocytes to metabolize a drug
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