How to Boc protect secondary amine on solid phase

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Facing issues when analyzing raw LC-MS/MS data with MS-DIAL?

I am facing a problem with my Waters MSe raw data. I have tried to open my raw data with AIF mode, after converting my file to ABF format for MS-DIAL, but everytime my system crashed. Later I...

14 June 2024 2,492 1 View

Can any biomarkers are secreted by cancerous cell?

specially biomarker secreted by the K-562 CANCER CELL

25 August 2023 7,102 1 View

Can we use ribitol as an internal standard for the untargeted GCMS metabolomics for phytochemical analysis?

I have seen in many papers that for plant phytochemical analysis using GC-MS people have used ribitol as an internal standard. But ribitol is already present in many plants. So, can we use it for...

25 June 2023 5,933 3 View

Internal standard for untargeted metabolomics?

what are the suitable internal standards for untargeted gcms metabolomics for phytochemical analysis?

22 June 2023 9,765 1 View

I only have noisy radar signals. How can I use an adaptive filter to denoise it as I do not have any reference signal?

I read somewhere that a delayed version of the noisy signal can be used as the reference signal but then how can we get a clean signal from giving a noisy signal as reference?

25 May 2023 5,759 0 View

Could you please send me these research papers?

Mokaddis , G. S and Zaki. S. S., The Problem Of The Queuing System M/M/1 With Additional Servers For A Longer Queue. Indian J . Pure Applied Math.1 Vol. 3, No. 3, PP.78-98, 2000. 2. The limit...

15 May 2023 1,836 0 View

Does anyone have the eBook of Stochastic Processes, Textbook in Slovene by Hudoklin-Bozic A.?

This book contains a model ,M/M/1 with additional Server for Longer queues. I need to read this book for my research purpose. I would be glad you if you can provide me a softcopy of this book ....

14 May 2023 4,839 0 View

Is there any lab for screening of in vitro wound healing activity of silver nanoparticles on HaCat Cell Lines in Delhi?

I have 3 nanoparticles and I want to screen it for in vitro wound healing activity on HaCat Cell lines. My lab doesn't has the facility for cell culture techniques and hence, I am looking for any...

30 April 2023 7,389 1 View

How can i lyophilize hexane and acetonitrile extract?

My lab has a lyophilizer whose minimum temperature reaches -55. Can anyone please tell me how can i lyophilize my hexane and acetonitrile extract

24 March 2023 693 1 View

What are range-time, range-doppler, time-Doppler, and velocity-time plots in the case of Radar sensor plots?

Let's have an FMCW radar sensor. I arrange the raw data in a matrix format with MXN dimensions, where M represents the number of time samples per chirp and N represents the total number of chirps....

20 January 2023 5,411 3 View

Conjugation of PEG-Amine to an Amino Acid Using EDC?

I am attempting to conjugate PEG to an amino acid at the C-terminus, for the purposes of producing nanoparticles. I have been told that PEG modified with amine groups can be used for this purpose,...

31 July 2024 2,033 1 View

How to remove/ replace trifluoroacetate countertop after deprotection?

After deprotection of the tert-butyl ester to generate the carboxylic acid in chloroform with TFA, my compound‘s pyridine moiety forms a TFacetate ammonium salt (small molecule drug, not a...

29 July 2024 9,753 3 View

When I am trying to distill triethyl amine while drying it over calcium hydride. How do I design the setup to let hydrogen escape without losing NEt3?

I am new to research. The boiling point of triethyl amine (NEt3) is 89 degrees centigrade. I am skeptical that when I will let the hydrogen escape which is getting generated in situ, I will also...

21 July 2024 7,284 4 View

Methods of O-methylation of amino acids without interfering the amine groups?

Hello guys. I have faced the problem of being in need of carboxyl-methylated amino acids. Amino acids I need are not available in the market so I need to synthesize them by myself. So thus I'm...

16 June 2024 9,920 3 View

How to purify Schiff base product?

How to stabilise the Schiff base product and avoid it from reverse back to the aldehyde and primary amine.

09 June 2024 9,264 5 View

How to select aminolysis reaction over transamidation reaction bw an amine and an amide ester?

Hi. i have a molecule it has both amide and ester bond. When i want to get second amide bond with ester part of the molecule by an amine, but it attacks to the amide bond also. In which conditions...

01 June 2024 9,863 2 View

Is there anyone that can assist be with removing excess 1-Iodo-Octane from from my product. Beside high vacuum distillation and kugelrohr what else?

I perform al alkylation reaction on an imdazole compound where the alkyl reagent (1-Iodo-Octane) was in excess. After the reaction was completed, I then performed an extraction, followed by...

24 May 2024 8,042 2 View

How can we perform HPLC for a uv inactive & highly polar compound?

I'm trying to synthesize a highly polar compound which is uv inactive (In TLC charring at the bottom- 0.1RF/20%MeOH:DCM ,MP) . I have confirmed the compound by simple mass and H'NMR spectrums but...

22 May 2024 9,818 3 View

Does anyone know how to Coat polystyrene particles with APTES ?

I want to have amine group attached on the polystyrene particle surface. APTES can be used to do that.

21 May 2024 8,092 0 View

How can I differentiate the -NH group in the backbone and -NH2 group in the side chain of my poly(glutamine) polymer sample?

I have synthesized a poly(glutamine) sample and am currently analyzing it using NMR spectroscopy. I am facing challenges in differentiating the -NH protons from the backbone of the structure and...

12 May 2024 9,656 7 View