AnnotationDbi can annotate gene with its full name or GO term.
However, how to annotate individual ligand-receptor pairs?
For example, KNG1-BDKRB2, how can you annotate its role or function with R or python module?
Wang Lu There is no universal method for annotating individual ligand-receptor pairings. However, utilizing multiple databases and APIs, you may retrieve information on the specific pair.
For example, the biomaRt package in R may be used to obtain functional information from databases like as UniProt, Ensembl, or Gene Ontology. Using the gene symbol or accession number, you may search these databases for pertinent information such as function, pathway, or interaction partners.
The Biopython library in Python gives access to numerous biological databases such as UniProt, Ensembl, and KEGG. Similarly, you may extract ligand and receptor information and utilize it to annotate the ligand-receptor pair.
It is vital to remember that the data available in the databases you are using may restrict the annotation of individual ligand-receptor pairings. Furthermore, the data may be incomplete and may not fully reflect the function of the specific ligand-receptor combination in issue.
To annotate individual ligand-receptor pairs, you can perform the following steps:
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