Can anyone suggest an efficient and standard method to analyze differences between cross-correlograms related to a group of pair recordings (each pair has a cross-correlogram) in different conditions ?

My aim is to assess statistical significance among cross-correlation values in 4 different conditions (each pair has four recording conditions). 

The software MiniAnalysis was used to calculate the cross-correlogram for each cell pair but it does not contain any routine to run this statistical analysis (I might double check but it seems to me it doesn't).

I have been suggested to use Bootstrap analysis or trial shuffling. I found so far only theoretical articles about both methods, none streamlining the procedure from a more practical standpoint. In addition, although I have understood the general meaning of these tests, I was wondering whether there are caveats or exceptions I should take into account, given that my "measures" are "repeated" for each element of the sample (each element/subject/pair has 4 measures that need to be compared). 

Last: I do have access to Matlab but I am not a matlab user, so any suggested method that would avoid the use of this software would be preferred.

Thank you

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