If we talk about electrolytes, we can use "Elect Wizard" to add chemical reactions and their products for simulations. But my concern is how we can add those kind of reactions for non-electrolytes in Aspen Plus to simulate a non-aqueous mixtures...
There are several reactor blocks on the Reactors tab in the Model Palette. Each block has one or more ways to specify the reactions and extent of conversion. For example, for the RStoic block, the balanced stoichiometry equation(s) and the extent of conversion(s) are specified on the Reactions tab.
In that case, first create a Reaction (below Utilities in the Simulation Navigation pane). Specify the Reaction ID, stoichiometry and whether it is kinetic or equilibrium type and give parameters. In the RadFrac block specification, specify the stages where the reaction occurs and give the Reaction ID. Alternatively, you can define a set of reactions under Chemistry in the Properties environment and then specify to use that Chemistry ID in Radfrac.