We all know that almost all syngenic tumor are very prone to be necrosed once the the tumor volume reaches 1000 mm^3.
Anyone have any idea how to run the efficacy beyond 1000 mm^3 tumor without tumor superficial necrosis/tumor ulcerations.
Any specific site of injection like posterior right flank subcutaneous site or any other site may help to overcome the tumor necrosis?
Tomas Koltai
Necrosis is a direct consequence of hypoxia and lack of nutrients due to relatively poor vascular supply as soon as a certain size is achieved.
The only way to avoid this is through implants in different sites. Once you have three or four implants, the total volume can be more than 1,000 as far as none of them reaches a critical size.
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