Please suggest anyone ,does span effects the dissolution? particle size is in the range but dissolution is not getting 100%. what could be the reason ?
By Span, do you mean the surfactant or the dimensionless measurement of the width of the distribution ( [x90 - x10]/x50)? If the latter different distributions can provide the same span and your material may be too large or contain large agglomerates for effective dissolution (especially if sparingly soluble). Please post the actual distribution.