Aerobic cells behavior under hypoxia conditions is mainly clear. At the same time, I cannot find data concerning cell responses to pyruvate lack. By clarifying these responses, one could better understand the functions of organism-scale physiological mechanisms directly or indirectly involved in the material support of ATP synthesis in mitochondria. In particular, the answer will promote (or not) the concept according to which the cardiovascular function is under modulation of specific chemical factors produced by cells in a condition of energy insufficiency.