PPIs get bonded with the H/K ATPase pump through sulfide bonding irreversibly and it takes 18-24 hours for a new pump to get synthesized .My query is that if the drug is bound at its receptor permanently how it will leave the body
My quick research online indicates that there is fairly rapid turnover of the parietal cells in which the H-K-ATPase, the target of PPIs, is found. Therefore, the covalent drug-target complex, or its proteolytic degradation products, is presumably shed along with the cells.
Article A focus on parietal cells as a renewing cell population