Blastocystis is an intestinal parasite of humans and wide range of organisms. The pathogenesis status of this organism is controversial. As I would like to study the association of this organism in human intestinal manifestations, I would like to know the in-silico and invivo methods which I can use to explore the pathogenesis of the Blastocystis. Could any one please help me out in this regard?
Hi, this links may be help you
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040727/
https://parasitesandvectors.biomedcentral.com/articles/10.1186/1756-3305-6-295
Blastocystis organisms isolated from humans have commonly been referred to as B. hominis. However, because of extensive genetic diversity (even among organisms isolated from humans) and low host specificity, the designation Blastocystis sp. is considered more appropriate.
The life cycle of Blastocystis sp. is not yet understood, including the infectious stage and whether (and which of the) various morphologic forms of this polymorphic organism that have been identified in stool or culture constitute distinct biologic stages of the parasite in the intestinal tract of hosts. The cyst form (3–5 µm) is postulated to be an infectious stage, but not confirmed. The predominant form found in human stool specimens is referred to as the vacuolar (or central body) form and is of variable size (5–40 µm, occasionally much larger). Replication appears to occur via binary fission. Other morphologic forms (e.g., ameboid and granular forms) also have been noted in stool samples and/or culture; their biological role and eventual developmental fate require further investigation.
https://www.cdc.gov/dpdx/blastocystis/index.html
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