Dear friend, it depends on the physical quantity you simulate and test. For complex quantities like optical response, heat flux, it is hard to say. A paper of mine is suggested for you, where a brief discussion is done. (
Method of Investigation for Numerical Simulation on Aero-Optical Effect Based on WCNS-E-5)
I advise you to investigate the process with relatively small Reynolds numbers and gradually increase their value by an order of magnitude. Check the adequacy of the model using the experiment.
It will be acceptable that the difference between the numerical results and experimental measurements are between 5 to 7 %. in condition of at least 7 to 15 points on graph for comparison.