It is highly appreciated if anybody introduces me a document regarding the comparison of the minimum weeks required for full protein glycation by ribose, fructose, and glucose.
In a study, after 4 weeks of incubation, fluorescence intensity of glucose-, fructose-, ribose-glycated BSA significantly increased over the fluorescence intensity of non-glycated BSA.
A study also reported 2 weeks. In general, 2 to 4 weeks will result in full protein glycation by ribose, fructose, and glucose.
This published paper by Grazyna et al. will give more explanation
I hope this Chabter is benefit to you ( Carbohydrates In book: Medical Biochemistry)
Chapter Carbohydrates
Methylglyoxal is formed from glucose in the diabetic patients we studied. When tested ,in vitro, methylglyoxal rapidly reacts with bovine serum albumin to form a solid in less than 5 minutes.The limiting step here is rate of formation of methylglyoxal. The formation of advanced glycation endproducts may begin througi the maillard reaction but protein changes could continue for years in vivo. I reccomend contacting Paul J. Thornalley in Dubai, I believe
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