I would like to know what are the genes involved in resistance to Isoniazid in Mycobacterium tuberculosis. I have found near 5 genes, but in so many paper the genes related are different. Thank you for helping.
Mutations in 2 genes account for the majority of the isoniazid (INH)-resistant strains: katG and inhA. Over 90% of INH-resistant isolates have mutation at the 315 katG codon. Other genes in which mutation for INH can occur are ahpC and KasA.
what can you tell me about the ndh gene? is it a gene involved in INH resistance? and i have seen that there are some mutations in the promoter of the gene inhA? is it right? Thank you for answering.
ndh gene is associated to inh resistance but its incidence in the global burden of MDR-TB is less important than other genes as inhA or katG. It's attached a reference of a paper talking about it:
DOI: 10.1590/S0074-02762007000100009
There are also mutations involving promoter of gene inhA.
Hope that this help you.
Toni
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