My question is mostly about how many spermatogenesis cycle does it take so all the spermatozoa are effected by a deficiency / treatment, and so the offspring is completely affected ? No matter if it's about a precise nutritious deficiency or a drug effect or anything. I wonder how long do we have to affect a male mouse, so all its spermatozoa will transmit a treatment effect to the offspring ?
Most of the studies about this kind of question make the mice follow a 8 to 10 weeks of treatment / diet, but I'd like evidences on why this amount of time ?
Every studies treating mice for 8 to 10 weeks never justify the duration of the treatment, but I precisely want justification on that.
I assume we consider 2 cycles of spermatogenesis so all the spermatozoa get affected by the deficiency, or it could be one full cycle of spermatogenesis after the deficiency is fully acquired, in which case the duration of the treatment will depend on the time needed to directly affect the mice, and then add a full spermatogenesis cycle. But did a research ever show it ? I cannot find anything about it on PudMed.
Thanks for your help.
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