How does COVID-19 affect Monocyte Migration Inhibitory Factor (MIF)?
MIF is decreased in Caco2 cells during SARS1 infection https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292640/
SARS1 N-glycoprotein has a specific binding to human MIF protein https://academicjournals.org/journal/AJMR/article-full-text-pdf/8DC094212114
SARS1 and SARS2 glycoproteins have a ¬90% match.
There are no reports for MIF levels of patients either for SARS1 or SARS2 , there are only suggestions to use anti-MIF therapy for SARS1
https://www.researchgate.net/publication/263406810_Role_for_macrophage_migration_inhibitory_factor_in_acute_respiratory_distress_syndrome
Nasir Mustafa thank you but I can't find any information about the levels of MIF or how it is affected in the study you mentioned
Nasir Mustafa I am searching for SARS specific research, MIF is known to increase in many deceases but there is evidence which suggests that it might not increase with SARS, if you hypothesize that the N-glycoprotein hasn't changed enough from SARS1 to SARS2 then MIF may be decreased instead since SARS1 binds to it, MIF is increased in ARDS you can read a paper here: https://www.researchgate.net/publication/263406810_Role_for_macrophage_migration_inhibitory_factor_in_acute_respiratory_distress_syndrome