Does someone know how 5,7-dihydroxytryptamine is transported into 5-HT neurons? Is it through the serotonin transporter SERT? Can SSRIs block 5,7-DHT lesions? Any paper suggesting this? I found only one paper saying that SERT-blockers don't prevent 5-HT depletion induced by 5,7 DHT (Brain Res. Choi S et al 2004), but since desipramine does prevent NE depletion, I'm a bit confused. What about the neurotoxic effect?
Thank you for your help.
Simon N Young
A paper in the European Journal of Pharmacology in 2008 (Article 5,7-Dihydroxitryptamine toxicity to serotonergic neurons in ...
) concluded that "Fluoxetine (0.1 μM) pre-treatment reduced 5,7-DHT-induced serotonergic neurotoxicity. These results indicate that the mechanism by which 5,7-DHT-induces serotonergic neurotoxicity is, at least partially, dependent on the toxin uptake by the serotonin transporter." This paper looked at the effect of 5,7-DHT in cultured serotonin neurons. This may have resulted in greater inhibition of the serotonin transporter than in the study by Choi which was done in the rats. It is possible that incomplete inhibition of the serotonin transporter will allow enough 5,7-DHT to get into 5-HT neurons to destroy them.
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