How to predict the Synergy of two drugs?

Is there any tool or program to predict the synergy of two drugs based on bioinformatics without experimental data. I've more than 30 active TCM compounds that target hypertension associated...

10 November 2019 6,158 3 View

How to convert macromolecule inhibitors from smiles format to mole2 format?

Hi @all !!! I have used mcule data base by structure-based virtual screening aginst target receptor. I have down loaded smile file and tried to genrate mole2 file using USCF chimera...

10 November 2018 2,444 8 View

Is there any bioinformatics program to find out the specific inhibitor and substrate for enzymatic activity assay of purified protein?

07 August 2017 8,644 2 View

Hi everybody! Kindly suggest me how to purify this protein?

This protein is GST-Tagged and also soluble. But I'm facing problem in the purification step.PBS buffer pH7.3 as a binding buffer and Tris-HCl + L-Glutathione (reduced )pH.8. this protein eluted...

01 February 2017 8,681 4 View

Hi everybody! Which kit of buffers is used at the initial stage of crystallization?

31 December 2016 9,004 4 View

How can I find out active core site and what is the effect of lysine succinylation on active coresite or vice versa?

10 November 2016 7,427 3 View

How to get required protein concentration for crystals?

Hi every body! i am trying to pool the protein concentration after removal of his tag from native protein for crystal but did not get required quantity. When I expressed, purified and concentrated...

02 March 2016 3,692 3 View

How Can I purify a protein from sediment?

31 December 2015 7,324 4 View

What is the production process of CaFe ferroalloys?

I looking for ferro calcium production process

03 March 2021 1,755 4 View

Which SAR dataset to use for generating coherency matrix and performing target decomposition (Description) ?

Working on chandrayaan-2 DFSAR data, there are three datasets available: 1) Slant range image data product: The slant range complex image file. Each pixel is represented by two 4-byte floating...

02 March 2021 8,481 3 View

How UAV or drone can be beneficial to better estimate crop yield?

As we know, crop yield estimation has been done traditionally with farmer's expert knowledge, deductive sampling in representative areas, and remote sensing with satellite imagery. Farmer's Expert...

01 March 2021 3,468 3 View

Which bacteria are suitable for quorum sensing screening?

I want to find a quorum sensing inhibitor from plant extracts. Klebsiella pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, and Streptococcus pneumoniae. I looked for these strains...

01 March 2021 7,675 3 View

Can water be extracted from Olivine?

I have always been interested in geology and wondered about how unique structures of materials behave in different circumstances. I stumbled upon Olivine, the magnesium iron silicate, and heard...

28 February 2021 7,330 4 View

What is the exact mechanism of the antimicrobial effect of local anesthetics?

The antimicrobial effect of local anesthetics has been known for more than 50 years, but it still seems to have an unclear mechanism of action. which bacteria? which concentration? etc etc. ....

27 February 2021 4,450 2 View

How does charge on working electrode changes with rising potential?

During performing CV of a GCE or modified GCE, we rise the potential in the first half of the cycle and reduce it in reverse half. During the first half, what is the nature of charge on GCE or...

25 February 2021 7,994 3 View

Uncertianiny in using dry or wet basis in mixing a sediment with fuel oil?

Hello I'm currently working on a topic related to studying the anaerobic biodegradation of TPH in marine sediments. In this work, sediment should be mixed with fuel oil to a concentration of 20 g...

24 February 2021 9,839 3 View

Advice on growing lactobacillus species in the lab?

Hello everyone, For part of my PhD project, I'm hoping to grow some lactobacillus species in the lab so that I can create standard curves for a qPCR quantification of a faecal sample. However, I...

24 February 2021 3,157 6 View

What is your preference for journals for publishing in the field of Hyperspectral Imaging or Remote sensing?

I believe that we need to share our experience in publishing in the field of Hyperspectral Imaging or remote sensing? What is the best journal that you publish with? What is the worst experience...

23 February 2021 3,411 4 View