Dear All,

Are the Tcra-J-alpha26 or Tcrb-D-beta2 and Tcrb-J-beta2.6 segments important to the TCR of OT-1 mouse?

If only the J and D segments are replaced by other segments (but Tcra-V2 and Tcrb-V5 remain), will the new TCR have the ability to target SIINFEKL-H-2Kb complexes?

Sincerely,

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