Dear All,
Are the Tcra-J-alpha26 or Tcrb-D-beta2 and Tcrb-J-beta2.6 segments important to the TCR of OT-1 mouse?
If only the J and D segments are replaced by other segments (but Tcra-V2 and Tcrb-V5 remain), will the new TCR have the ability to target SIINFEKL-H-2Kb complexes?
Sincerely,