Under normal conditions hydrazine does not react with alcoholic OH groups. You can make the Wolff-Kishner reduction of ketones to hydrocarbons in ethylene glycole as solvent, that means that alcohols are inert to hydrazine. Also hydrogenations of nitrocompounds to anilines with hydrazine als reduction reagent can be made in ethanol under Pd/C catalysis without affecting the solvent.
@Burkhard koehler I did many reduction reactions in the same way u mentioned ( hydrazine monohydrate 99% in the present of pd/c 10% in ethanol) reflx 10-12 hr to reduce nitro compounds to anilines but they did not work!! Could u plz help me what do u think why it doesn't work! All chemicals are new except Pd/c !! Do u think this may effect the Rxn ?
I will be appreciate for you
I made this reaction many years ago and it worked with nearly quantitative yield. Perhaps you have a reactant which complexes an deactivates the Pd/C. Other catalysts for this reaction are Raney nickel, Fe(O)HO, Ce oxide doped with Sn oxide, Zn salts and Pt catalysts. Perhaps you should try one of these catalysts, starting with Raney-Ni.
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