How effective is the use of nanomaterials as a transport for smart drugs such as nano-silver?
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Organic or inorganic stable polymers are using as a potential candidates for delivering purposes of many drugs. Silver nanoparticles also an one of successful approach.
We have tested organic polymers such as chitin and pectin for individual or combine with drugs for studying the positive immune activites.
In vivo studies showed the nanoparticles such as pectin or Ag composites may effectively promote positive immune functions against bacterial infections and wound healing when applying topically. You may need to think what main purposes you are targeting also minimum the host reactivity against your vehicle nano materials. Good luck your work...
Nanomaterial is very much effective for targeted drug delivery. For an example if you make a heterostructure of your drug with a targeted agent (like magnetic material Fe2O3 etc.) you can guide your drug to particular place with proper precision. This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticle-mediated drug delivery in order to combat the downfalls of conventional drug delivery. It reduces the side effect of medicine.
There are different types of drug delivery vehicles, such as polymeric micelles, liposomes, lipoprotein-based drug carriers, nano-particle drug carriers, dendrimers, etc. An ideal drug delivery vehicle must be non-toxic, biocompatible, non-immunogenic, biodegradable, and must avoid recognition by the host's defense mechanisms.
A schematic of targeted drug delivery is attached (source-google)
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Several studies have been proved that magnetic nanoparticles (elements: Fe, Co, Ni, bi-element alloys, oxides: Fe3O4, gama-Fe2O3) are very attractive mechanism to be used as a targeted drug delivery to a particular part in the body. This kinetic should satisfy some criteria to be used for biomedical purposes:
- magnetic particles should be of suitable sizes with narrow size distribution to avoid any blocking at capillaries during blood cycle.
- magnetic particles should also have higher magnetic moments and higher magnetic susceptibility so that it can be guided externally with suitable magnetic field
- high chemophysical stability and avoiding any particle agglomeration
- the drug is to be attached to the magnetic core using a coupling layer (core – shell) the particle (core magnet + coupling layer and drugs) have to be biocompatible, nontoxic, biodegradable and Non–immunogenic
- Rapid distribution to organs and tissues
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