Sometimes, while screening natural products for antimicrobial / anti-infective potential, the results do not show any pattern; i.e. with increase in concentration either there is no increase in efficacy, OR even more complicated situation arises when lower efficacy is observed at higher concentrations.
How can this be explained? Anything other than 'eagle effect'?
Giridhar Kalidasu
You should take the help of appropriate statistics, otherwise the patterns are deceptive.
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David E. Bautista-Erazo
At higher concentrations some compounds tend to aggregate and maybe the sole compound has better activity than tghe aggregate. I don't know, it's just an idea.
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