Recently I bought some Thioflavin T (HY-D0218) from MCE. I'm curious that does Thioflavin T fluoresce when there is no amyloid aggregation? Does its fluorescence property depend solely on binding to aggregated amyloid? Thanks in advance!
Qiu Weiwei
Thioflavin T is capable of exhibiting fluorescence even in the absence of amyloid protein aggregation (Ex/Em: 350/438 nm). However, upon amyloid aggregation, the characteristic fluorescence used for detection is observed at Ex/Em: 450/482 nm (Reference: PMID: 2729542).
The answer to this question comes from MedChemExpress (MCE) Technical Support.
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